ctcf: first multivalent nuclear factor
| PAG Title | ctcf: first multivalent nuclear factor |
| PAG ID | WAG001240 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | CTCF is central to sigling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF? Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic ictivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptiol activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is bo fide ¿ltivalent?D-sequence binder which specificity is mediated by different sets of zinc fingers (ZFs). For three different D target sites, particular groups of ZFs which cannot be deleted from the 11 ZF domain without loosing binding to a given site, are shown by a ¿inbow?in the box on the left. |
| Species | Homo sapiens |
| nCoCo Score | 1,369 |
| Base PAG ID | WAG001240 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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